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Direct interactions between the human insula and hippocampus during memory encoding

delete2025-07-14
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AI
W
Weichen Huang
D
Dian Lyu
J
James Stieger
I
Ian H. Gotlib
V
Vivek Buch
A
Anthony D. Wagner
J
Josef Parvizi *
DOI:10.1038/s41593-025-02005-1delete
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摘要

摘要

En 中文
海马体对于编码情景记忆至关重要,但其在这一过程中与皮层区域的交互机制尚不明确。本研究中,16名植入了岛叶(217个位点)和海马体(131个位点)电极的受试者观看了具有情绪效价的词语并尝试回忆。编码期间,岛叶神经元群体的一组亚群在周期性活动中显示出变化,这些变化预测了成功的回忆。这些岛叶变化跟随海马体θ波但领先于海马体涟波。另一组岛叶位点则对词语效价做出反应,与记忆表现无关。对与记忆相关的岛叶位点进行直接电刺激诱发了同侧海马体的早期反应,而对与效价相关的位点进行刺激则未产生反应。相反,刺激海马体位点产生了缓慢且可变的信号,遍布所有岛叶位点,表明海马体与岛叶之间存在不对称的通信。这些发现为海马体与特定皮层结构内功能选择性神经元群体之间的中尺度交互提供了初步见解。海马体与岛叶在处理情绪记忆时进行通信。人类岛叶皮层的特定位点显示出预测后续记忆回忆的变化,而其他位点则对情绪内容做出反应。

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Nature Neuroscience 封面图
Nature Neuroscience
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20
论文数:
640
被引数:
7.1W

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department of neurosurgery
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department of psychology
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laboratory of behavioral and cognitive neuroscience
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4
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