Direct methylation sequencing

Abdulkadir Abakir

doi:10.1038/s41589-023-01356-9

Direct methylation sequencing

2023-06-15

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DOI：10.1038/s41589-023-01356-9

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摘要

En 中文

Sodium bisulfite is widely used in methylation sequencing, yet it degrades DNA, and on its own, it does not discriminate methylated cytosine from its oxidized derivative, 5-hydroxymethylcytosine. A new bisulfite-free technique uses enzymatic modification of DNA for direct and accurate methylation mapping.

Keyword:

DNA

5-HYDROXYMETHYLCYTOSINE

Direct methylation sequencing

摘要

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