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Disentangling direct and indirect genetic pathways to neurodevelopmental risk: brain structure and behavior in a population-based parent–offspring trio study

delete2026-07-30
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F
Fin J. E. van Uum *
Y
Yllza Xerxa
A
Alexander Neumann
J
Jean-Baptiste Pingault
C
Charlotte A. M. Cecil
M
Mina Shahisavandi
K
Koen Bolhuis
B
Boglarka Kovacs
H
Henning Tiemeier
R
Ryan L. Muetzel
N
Neeltje E. M. van Haren
DOI:10.1111/jcpp.70184delete
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Abstract

Abstract

En 中文
Neurodevelopmental disorders (NDDs) are highly heritable, yet the pathways linking parental genetic liability to child outcomes remain poorly understood. Traditional designs cannot easily separate genes transmitted to the child from environmental influences shaped by parental genotypes.
Keywords:
Neurodevelopmental disorders
polygenic scores
intergenerational transmission
brain structure
ADHD
MDD
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Journal

J
Journal of Child Psychology and Psychiatry
IF:
7
Papers:
4.6K
Citations:
2.3W

Organization

U
university college london
Scholars:
7.4K
Papers: 4.1K
Citations: 1
E
Erasmus University Medical Center
Scholars:
1.1K
Papers: 315
Citations: 0