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Disrupted Brain Connectivity in Newborns Following Antenatal Opioid Exposure
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DOI：10.1016/j.bpsc.2025.09.011.png)
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Abstract
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The neural bases of adverse neurodevelopmental outcomes in antenatal opioid exposure are poorly understood. Very limited in vivo human newborn imaging studies have reported disrupted functional connectivity (FC) in limbic and reward-related brain regions, but these studies used small samples and lacked matched controls. Our objective was to compare brain FC in antenatal opioid-exposed and unexposed newborns to study the impact of opioid exposure on early brain development.
Keywords:
antenatal opioid exposure
resting-state functional MRI
newborn brain imaging
OBOE
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