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Disrupted WWOX-MYC interplay impairs neurogenesis in human brain organoids

delete2026-07-03
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OA
AI
D
Daniel J Steinberg
A
Asia Zonca
D
Dania Abdellatif
I
Idan Rosh
I
Irina Kustanovich
O
Osama Hidmi
C
Carlo Manenti
K
Kian Maroun
J
Jose Davila-Velderrain
R
Rami I Aqeilan *
DOI：10.1093/brain/awag239delete
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Abstract

Abstract

En 中文
WOREE and SCAR12 syndromes are rare neurodevelopmental disorders caused by WWOX mutations, severely impairing brain development. The pleiotropic nature of WWOX complicates identifying specific mechanisms, thus, the specific molecular pathways affected by WWOX deficiency and how they contribute to disease pathogenesis remain largely unknown.

Journal

Brain cover
Brain
IF:
11.7
Papers:
1.4W
Citations:
6.3W

Organization

H
Human Technopole
Scholars:
403
Papers: 179
Citations: 540
H
hebrew university-hadassah medical school
Scholars:
17
Papers: 6
Citations: 0
U
university of haifa
Scholars:
950
Papers: 529
Citations: 0
Cited Papers

Cited Papers

Citing Papers

Citing Papers