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Dissecting the mechanistic actions of kaempferol in breast and ovarian cancers: pathway-level insights and translational potential
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DOI：10.3389/fonc.2026.1880434.png)
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Abstract
En 中文
Breast and ovarian cancers represent the major contributors to cancer-related mortality among women globally. To overcome chemoresistance and other mechanisms of therapeutic escape; kaempferol- a dietary flavonoid present in fruits and vegetables- has gained attention for its marked anticancer; anti-inflammatory; and antioxidant activities; positioning it as a promising therapeutic candidate. Preclinical studies indicate that kaempferol exerts multiple antitumour effects by promoting ROS generation; inducing DNA damage; upregulating pro-apoptotic and downregulating anti-apoptotic proteins; triggering G2/M phase cell-cycle arrest; inhibiting angiogenesis; suppressing epithelial-to-mesenchymal transitions; and reversing chemoresistance in both breast and ovarian cancers. When combined with conventional chemotherapeutic agents; kaempferol has shown potential to inhibit tumour growth and progression. However; despite promising preclinical studies; the molecular mechanism underlying it remains incompletely understood; and clinical evidence on its therapeutic efficacy is still limited. This review critically examines the current literature on kaempferol-mediated anticancer mechanisms in breast and ovarian cancers; evaluates its potential role in combination therapy; and outlines the key challenges and future directions required for translating these findings into clinical applications.
Keywords:
apoptosis
breast cancer
ovarian cancer
metastasis
kaempferol
Journal
IF:
3.3
Papers:
3.4W
Citations:
9.5W
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Cited Papers