.png){kind=icon}
返回
Distributed context-dependent choice information in mouse posterior cortex
.png){kind=icon}
OA
AI
DOI：10.1038/s41467-023-35824-6.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
In the posterior cortex, which is involved in decision making, the strength and area specificity of choice signals are highly variable. Here the authors show that the representation of choice in the posterior area of the mouse brain is orthogonal to that of sensory and movement-related signals, with modulations determined by task features and cognitive demands. Choice information appears in multi-area brain networks mixed with sensory, motor, and cognitive variables. In the posterior cortex-traditionally implicated in decision computations-the presence, strength, and area specificity of choice signals are highly variable, limiting a cohesive understanding of their computational significance. Examining the mesoscale activity in the mouse posterior cortex during a visual task, we found that choice signals defined a decision variable in a low-dimensional embedding space with a prominent contribution along the ventral visual stream. Their subspace was near-orthogonal to concurrently represented sensory and motor-related activations, with modulations by task difficulty and by the animals' attention state. A recurrent neural network trained with animals' choices revealed an equivalent decision variable whose context-dependent dynamics agreed with that of the neural data. Our results demonstrated an independent, multi-area decision variable in the posterior cortex, controlled by task features and cognitive demands, possibly linked to contextual inference computations in dynamic animal-environment interactions.
Keyword:
DECISION-MAKING
CORTICAL ACTIVITY
NEURONS
RESPONSES
DYNAMICS
REPRESENTATION
ATTENTION
INFERENCE
MOVEMENT
CIRCUITS
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
15.7
论文数:
9.4W
被引数:
91.2W
机构
引用论文
分享收藏Global Representations of Goal-Directed Behavior in Distinct Cell Types of Mouse Neocortex.png)
NEURONOAAI
NEURONIF15
OAAI分享收藏
查看更多内容