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DNA Computing Boosted by a Cationic Copolymer
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DOI：10.1002/adfm.201707406.png)
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摘要
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The huge information storage capability of DNA and its ability to self-assemble can be harnessed to enable massively parallel computing in a small space. DNA-based logic gates are designed that rely on DNA strand displacement reactions; however, computation is slow due to time-consuming DNA reassembly processes and prone to failure as DNA is susceptible to degradation by nucleases and under certain solution conditions. Here, it is shown that the presence of a cationic copolymer boosts the speed of DNA logic gate operations that involve multiple and parallel strand displacement reactions. Two kinds of DNA molecular operations, one based on a translator gate and one on a seesaw gate, are successfully enhanced by the copolymer without tuning of computing conditions or DNA sequences. The copolymer markedly reduces operation times from hours to minutes. Moreover, the copolymer enhances nuclease resistance.
Keyword:
copolymers
DNA
logic gates
speed-up
strand displacement reactions
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19
论文数:
3.5W
被引数:
32.1W
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引用论文
DNA strand exchange stimulated by spontaneous complex formation with cationic comb-type copolymer
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On the biophysics and kinetics of toehold-mediated DNA strand displacement关于脚趾介导的DNA链置换的生物物理学和动力学.png)
NUCLEIC ACIDS RESEARCH
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NUCLEIC ACIDS RESEARCHIF13.1
OAAI分享收藏Comb-type cationic copolymer expedites DNA strand exchange while stabilizing DNA duplex梳型阳离子共聚物加速DNA链交换，同时稳定DNA双链体
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