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DNA Damage Response
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DOI：10.1101/cshperspect.a000745.png)
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摘要
En 中文
Structural changes to DNA severely affect its functions, such as replication and transcription, and play a major role in age-related diseases and cancer. A complicated and entangled network of DNA damage response (DDR) mechanisms, including multiple DNA repair pathways, damage tolerance processes, and cell-cycle checkpoints safeguard genomic integrity. Like transcription and replication, DDR is a chromatin-associated process that is generally tightly controlled in time and space. As DNA damage can occur at any time on any genomic location, a specialized spatio-temporal orchestration of this defense apparatus is required.
Keyword:
NUCLEOTIDE EXCISION-REPAIR
DOUBLE-STRAND BREAKS
RNA-POLYMERASE-II
CHROMATIN REMODELING COMPLEXES
IN-SITU VISUALIZATION
PIGMENTOSUM GROUP-E
GROUP-C PROTEIN
MAMMALIAN-CELLS
HOMOLOGOUS RECOMBINATION
LIVING CELLS
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10.1
论文数:
3.0K
被引数:
1.3W
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