.png){kind=icon}
返回
DNA structure and function
.png){kind=icon}
OA
AI
DOI：10.1111/febs.13307.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
The proposal of a double-helical structure for DNA over 60 years ago provided an eminently satisfying explanation for the heritability of genetic information. But why is DNA, and not RNA, now the dominant biological information store? We argue that, in addition to its coding function, the ability of DNA, unlike RNA, to adopt a B-DNA structure confers advantages both for information accessibility and for packaging. The information encoded by DNA is both digital - the precise base specifying, for example, amino acid sequences - and analogue. The latter determines the sequence-dependent physicochemical properties of DNA, for example, its stiffness and susceptibility to strand separation. Most importantly, DNA chirality enables the formation of supercoiling under torsional stress. We review recent evidence suggesting that DNA supercoiling, particularly that generated by DNA translocases, is a major driver of gene regulation and patterns of chromosomal gene organization, and in its guise as a promoter of DNA packaging enables DNA to act as an energy store to facilitate the passage of translocating enzymes such as RNA polymerase.
Keyword:
A-DNA
B-DNA
alternative DNA structures
DNA as an energy store
DNA backbone conformation
DNA elasticity
DNA information
DNA structure
DNA topology
genome organisation
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
4.2
论文数:
9.0K
被引数:
2.6W
机构
引用论文
DYNAMICS OF SEDIMENTATION AND USE OF GENETIC ALGORITHMS FOR ESTIMATING SEDIMENT YIELDS IN A RIVER: A CRITICAL REVIEW河流中的沉积动力学及利用遗传算法估算泥沙产量的研究：一项批判性综述
PREAI
分享收藏
Temperature Dependence of the DNA Double Helix at the Nanoscale: Structure, Elasticity, and Fluctuations.png)
BIOPHYSICAL JOURNALOAAI
BIOPHYSICAL JOURNALIF3.1
OAAI分享收藏Smoking experimentation and initiation among adolescent girls: qualitative and quantitative findingsOAAI
OAAI分享收藏
查看更多内容