.png){kind=icon}
返回
Does exposure to PM10 decrease age at menarche?
.png){kind=icon}
PRE
AI
DOI：10.1016/j.envint.2018.04.020.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Background: There has been a consistent decrease in age at menarche in South Korea. A potential risk factor for early menarche is exposure to particulate matter (PM), because endocrine-disrupting compounds emitted into air from anthropogenic sources may be incorporated into PM. The objective of this study was to examine the association between pre-menarcheal exposure to PM <= 10 mu m in diameter (PM10) and age at menarche in adolescents of South Korea using Korea National Health and Nutrition Examination Survey (KNHANES) 2010-2012 data. Methods: We used self-reported age at menarche of 639 girls aged 13-17 years in this study. The cut-off age for early menarche was set to 12 years. Based on each subject's address, 1-year, 2-year, and 3-year averages of annual mean PM10 concentrations (models 1-3) were linked to KNHANES. Models were adjusted for body mass index (BMI), city size, household income level, maternal age at menarche, and second-hand smoke exposure at home. SURVEYREG and SURVEYLOGISTIC procedures were used to address the complex survey design of KNHANES. Results: Overall analysis showed that exposure to PM10 has a significant effect on decreasing age at menarche. Multiple linear regression results suggested that each 1 mu g/m(3) increase in 1-year, 2-year, 3-year averages of annual mean PM10 concentrations accelerated age at menarche by 0.046 years (95% CI: -0.064, -0.027; p <.0001), 0.038 years (95% CI: -0.059, -0.018; p=0.0003), and 0.031 years (95% CI: -0.047, -0.015; p=0.0002), respectively. Adjusted ORs for a 1 mu g/m(3) increase in PM10 concentration were 1.08 (95% CI: 1.04 -1.12) for model 1, 1.06 (95% CI: 1.02 -1.10) for model 2, and 1.05 (95% CI: 1.01 -1.09) for model 3. Conclusion: Our findings suggest that elevated PM10 concentration can decrease age at menarche. This is the first study that investigates the association between exposure to PM10 and age at menarche using a nationally representative sample of Koreans.
Keyword:
Menarche
Particulate matter
EDCs
KNHANES
Korea
Female adolescents
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
9.7
论文数:
1.0W
被引数:
7.7W
机构
引用论文
Erythroid-Specific Transcriptional Changes in PBMCs from Pulmonary Hypertension Patients.png)
PLoS ONE
OAAI
PLoS ONEIF0
OAAI分享收藏Early menarche is associated with increased risk of asthma: Prospective population-based study of twins初潮早期与哮喘风险增加相关: 基于双胞胎的前瞻性人群研究RESPIRATORY MEDICINEOAAI
RESPIRATORY MEDICINEIF3.1
OAAI分享收藏
查看更多内容