.png){kind=icon}
返回
Does IIH Alter Brain Microstructures? - A DTI-Based Approach
.png){kind=icon}
PRE
AI
DOI：10.1111/head.13039.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
IntroductionTo investigate the correlation of microstructural parameters with CSF pressure and macroscopic changes assessed by diffusion tensor imaging (DTI) in patients with idiopathic intracranial hypertension (IIH). MethodsTwenty-three patients with IIH as well as age-, sex-, and body mass index (BMI)-matched controls underwent high resolution MR imaging of the optic nerve sheaths (ONS), pituitary gland, and ventricles. For DTI data a voxelwise permutation analysis was performed for the whole brain and ROI analysis was performed for the optic nerve and optic radiation. DTI measurements were correlated to morphometric measurements, CSF opening pressure, and headache intensity. The reliability of diagnostic performance of DTI parameters was assessed using ROC analysis. ResultsAnalysis of DTI metrics revealed a significant reduction in the fractional anisotropy (FA) of the optic nerve in patients with IIH. In contrast, systematic regional variations between IIH patients and controls were neither observed in the whole brain analysis nor in the optic radiation. FA values of the optic nerve show significant correlations with the optic nerve sheath diameter (P=.003, r=-.589). The correlation of the alterations of the FA values of the optic radiation and the whole brain do not show a significant association to morphometric alterations in the ONS diameter and hypophysis height as well as to CSF opening pressure and headache intensity. ConclusionsThe results indicate that IIH is associated with microstructural changes in the optic nerve. These alterations may be the direct consequence of chronically elevated intracranial pressure.
Keyword:
headache
idiopathic intracranial hypertension
pain
MRI
DTI
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
H
IF:
4
论文数:
6.0K
被引数:
1.0W
机构
引用论文
Revised diagnostic criteria for the pseudotumor cerebri syndrome in adults and children.png)
NEUROLOGY
NEUROLOGYIF8.5
PREAI
分享收藏Increased expression of ATP‐binding cassette transporters in enfortumab vedotin‐resistant urothelial cancerenfortumab vedotin耐药尿路上皮癌中 ATP 结合盒转运蛋白的表达增加
OAAI
OAAI分享收藏分享收藏The International Classification of Headache Disorders, 3rd edition (beta version)国际头痛疾病分类，第3版 (beta版)CEPHALALGIA
OAAI
CEPHALALGIAIF4.6
OAAI分享收藏
查看更多内容