Double-checking chromosome segregation

Hélder Maiato

doi:10.1083/jcb.202301106

2023-04-05

Hélder Maiato *

Sónia Silva

DOI：10.1083/jcb.202301106

原文链接

查看原文

摘要

En 中文

Enduring chromosome segregation errors represent potential threats to genomic stability due to eventual chromosome copy number alterations (aneuploidy) and formation of micronuclei-key intermediates of a rapid mutational process known as chromothripsis that is found in cancer and congenital disorders. The spindle assembly checkpoint (SAC) has been viewed as the sole surveillance mechanism that prevents chromosome segregation errors during mitosis and meiosis. However, different types of chromosome segregation errors stemming from incorrect kinetochore-microtubule attachments satisfy the SAC and are more frequent than previously anticipated. Remarkably, recent works have unveiled that most of these errors are corrected during anaphase and only rarely result in aneuploidy or formation of micronuclei. Here, we discuss recent progress in our understanding of the origin and fate of chromosome segregation errors that satisfy the SAC and shed light on the surveillance, correction, and clearance mechanisms that prevent their transmission, to preserve genomic stability. Maiato and Silva discuss the origin and fate of chromosome segregation errors that satisfy the spindle assembly checkpoint, focusing on anaphase surveillance/correction mechanisms and post-mitotic clearance pathways.

Keyword:

MEROTELIC KINETOCHORE ORIENTATION

SPINDLE-ASSEMBLY CHECKPOINT

AURORA-B-KINASE

ERROR-PRONE

MICROTUBULE DYNAMICS

LAGGING CHROMOSOMES

PASSENGER COMPLEX

MIS-SEGREGATION

MITOTIC CHECKPOINT

CDK1 INACTIVATION

AI总结

对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。

期刊

Journal of Cell Biology

IF:

6.4

论文数:

1.2W

被引数:

5.7W

机构

Universidade do Porto

学者数:

3.0W

论文数: 2.9W

被引数: 34

引用论文

Disruption of Smad7 Promotes ANG II-Mediated Renal Inflammation and Fibrosis via Sp1-TGF-β/Smad3-NF.κB-Dependent Mechanisms in Mice

PLoS ONE

IF0

2013-01-03

OAAI

Guan-Xian Liu; You-Qi Li; Xiao R. Huang; Lihua Wei; Hai-Yong Chen; Yong-Jun Shi; Rainer L. Heuchel; Hui Y. Lan

Axonal connections of a forebrain nucleus involved with vocal learning in zebra finches

Journal of Comparative Neurology

IF0

2004-10-09

PREAI

Sarah W. Bottjer; Keri A. Halsema; Sandra A. Brown; Elizabeth A. Miesner

Memory Systems of 1999

The Oxford Handbook of Memory

IF0

2000-05-04

PREAI

Daniell. Schacter; Anthony D Wagner; Randy L Buckner

Effects of Weight Loss on Mechanisms of Hyperglycemia in Obese Non-Insulin-Dependent Diabetes Mellitus

Diabetes

IF0

1986-09-01

PREAI

R R Henry; P Wallace; J M Olefsky

Genome doubling shapes the evolution and prognosis of advanced cancers 基因组加倍塑造晚期癌症的进化和预后

NATURE GENETICS

IF31.8

2018-07-16

402

OAAI

Bielski, Craig M.; Zehir, Ahmet; Penson, Alexander V.; Donoghue, Mark T. A.; Chatila, Walid; Armenia, Joshua; Chang, Matthew T.; Schram, Alison M.; Jonsson, Philip; Bandlamudi, Chaitanya; Razavi, Pedram; Iyer, Gopa; Robson, Mark E.; Stadler, Zsofia K.; Schultz, Nikolaus; Baselga, Jose; Solit, David B.; Hyman, David M.; Berger, Michael F.; Taylor, Barry S.

ENVIRONMENTAL RESEARCH

IF7.7

2020-01-01

PREAI

Hopf, Nancy B.; Danuser, Brigitta; Bolognesi, Claudia; Wild, Pascal

Tolerance of Whole-Genome Doubling Propagates Chromosomal Instability and Accelerates Cancer Genome Evolution

CANCER DISCOVERY

IF33.3

2014-02-04

345

OAAI

Dewhurst, Sally M.; McGranahan, Nicholas; Burrell, Rebecca A.; Rowan, Andrew J.; Groenroos, Eva; Endesfelder, David; Joshi, Tejal; Mouradov, Dmitri; Gibbs, Peter; Ward, Robyn L.; Hawkins, Nicholas J.; Szallasi, Zoltan; Sieber, Oliver M.; Swanton, Charles

Aurora B and Kif2A control microtubule length for assembly of a functional central spindle during anaphase

JOURNAL OF CELL BIOLOGY

IF6.4

2013-08-19

OAAI

Uehara, Ryota; Tsukada, Yuki; Kamasaki, Tomoko; Poser, Ina; Yoda, Kinya; Gerlich, Daniel W.; Goshima, Gohta

Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing 使用全基因组测序对2,658种人类癌症中的色素病进行综合分析

NATURE GENETICS

IF31.8

2020-02-05

292

OAAI

Cortes-Ciriano, Isidro; Lee, Jake June-Koo; Xi, Ruibin; Jain, Dhawal; Jung, Youngsook L.; Yang, Lixing; Gordenin, Dmitry; Klimczak, Leszek J.; Zhang, Cheng-Zhong; Pellman, David S.; Park, Peter J.; Akdemir, Kadir C.; Alvarez, Eva G.; Baez-Ortega, Adrian; Beroukhim, Rameen; Boutros, Paul C.; Bowtell, David D. L.; Brors, Benedikt; Burns, Kathleen H.; Campbell, Peter J.; Chan, Kin; Chen, Ken; Dueso-Barroso, Ana; Dunford, Andrew J.; Edwards, Paul A.; Estivill, Xavier; Etemadmoghadam, Dariush; Feuerbach, Lars; Fink, J. Lynn; Frenkel-Morgenstern, Milana; Garsed, Dale W.; Gerstein, Mark; Gordenin, Dmitry A.; Haan, David; Haber, James E.; Hess, Julian M.; Hutter, Barbara; Imielinski, Marcin; Jones, David T. W.; Ju, Young Seok; Kazanov, Marat D.; Koh, Youngil; Korbel, Jan O.; Kumar, Kiran; Lee, Eunjung Alice; Li, Yilong; Lynch, Andy G.; Macintyre, Geoff; Markowetz, Florian; Martincorena, Inigo; Martinez-Fundichely, Alexander; Miyano, Satoru; Nakagawa, Hidewaki; Navarro, Fabio C. P.; Ossowski, Stephan; Pearson, John, V; Puiggros, Montserrat; Rippe, Karsten; Roberts, Nicola D.; Roberts, Steven A.; Rodriguez-Martin, Bernardo; Schumacher, Steven E.; Scully, Ralph; Shackleton, Mark; Sidiropoulos, Nikos; Sieverling, Lina; Stewart, Chip; Torrents, David; Tubio, Jose M. C.; Villasante, Izar; Waddell, Nicola; Wala, Jeremiah A.; Weischenfeldt, Joachim; Yao, Xiaotong; Yoon, Sung-Soo; Zamora, Jorge

Use and effectiveness of tocilizumab among patients with rheumatoid arthritis: an observational study from the British Society for Rheumatology Biologics Register for rheumatoid arthritis

Clinical Rheumatology

IF0

2016-12-02

OAAI

Mari Kihara; Rebecca Davies; Lianne Kearsley-Fleet; Kath D. Watson; Mark Lunt; Deborah P.M. Symmons; Kimme L. Hyrich

查看更多内容