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Downregulation of COX-2 expression in liver sinusoidal endothelial cell prevented the formation of liver sinusoidal microthrombi through the AKT/mTOR/TSP-1 axis
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DOI：10.1016/j.phrs.2026.108356.png)
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Abstract
En 中文
• Upregulation of COX‑2 in LSECs of cirrhotic patients and pIVCL model with LST • Alleviation of LST and portal hypertension in pIVCL model by LSEC-specific Ptgs2 knockout • Alleviation of LST and portal hypertension in the pIVCL model treated by celecoxib • Downregulation of TSP-1 by celecoxib via AKT/mTOR signaling pathway alleviates LST • Regulation of TSP-1 by COX-2 via lactate accumulation and histone lactylation
Keywords:
liver sinusoidal microthrombosis
portal hypertension
cyclooxygenase-2
thrombospondin-1
lactate
histone lactylation
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