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Doxycycline and IGF-1 as a synergistic combination therapy for OA disease modification
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DOI：10.1016/j.biopha.2025.118897.png)
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Abstract
En 中文
• A synergistic drug combination of Dox & IGF-1 for OA amelioration in goat explants. • Targeting multiple pathways – NF-κB /c-Jun-JNK. • Mechanistic understanding of the combination therapy. • Validation in human explants for improved clinical relevance. • Reversal of OA-like conditions ex vivo in two weeks.
Keywords:
Osteoarthritis
DMOADs
Doxycycline
IGF-1
Synergistic combination therapy
Multifactorial pathogenesis of osteoarthritis
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7.5
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1.6W
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8.2W
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