Dried Blood Spot: A Tool to Ensure Broad Access to Hepatitis D Screening, Diagnosis, and Treatment Monitoring

2026-06-19

Rola Matar

Françoise Roudot-Thoraval

Valérie Ortonne

Olivia Garrigou

Alexandre Soulier

Pierre Cappy

Daniel Candotti

Patrick Ingiliz

Jean–Michel Pawlotsky

Vincent Leroy

Stéphane Chevaliez *

DOI：10.1111/liv.70759

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Chronic hepatitis D is the most severe form of viral hepatitis. Despite recommendations for systematic screening of HBsAg-positive individuals, hepatitis D infection remains underdiagnosed. Standard HDV virological markers are classically assessed in serum or plasma specimens obtained through venous whole blood sampling. This approach is costly and challenging in resource-limited settings. Dried blood spot (DBS) sampling offers a practical alternative for large-scale screening, diagnosis, and monitoring of viral hepatitis. The goal of the study is to evaluate the performance of commercially available HDV diagnostic assays using DBS.

Keywords:

diagnosis

dried blood spot

hepatitis D virus

monitoring of HDV infection

screening

Dried Blood Spot: A Tool to Ensure Broad Access to Hepatitis D Screening, Diagnosis, and Treatment Monitoring

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