.png){kind=icon}
.png){kind=icon}
Return
Dual Beclin 1 post-translational reprogramming by BCR-ABL and HDAC6 inhibition disables autophagic flux and overcomes CML resistance
.png){kind=icon}
OA
AI
J
Y
V
B
G
C
M
M
DOI：10.1016/j.canlet.2026.218755.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
• Asciminib dephosphorylates Beclin 1, priming it for p300-dependent acetylation • HDAC6 inhibition by 7b enables Beclin 1 acetylation and blocks autophagic flux • Asciminib+7b induces caspase-3/-6-independent, z-VAD-insensitive death in resistant CML • Resistant CML cell death is accompanied by ICD-associated DAMP emission
Keywords:
Chronic myeloid leukemia
Resistance
Autophagy
HDAC6
Beclin 1
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
10.1
Papers:
1.7W
Citations:
4.3W
Organization
Cited Papers