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Dual explainability framework for heart disease prediction using LIME and permutation feature importance
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DOI：10.1007/s42452-025-08108-5.png)
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Abstract
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Heart disease continues to be one of the leading causes of mortality worldwide, which highlights the immediate need for accurate and interpretable predictive models to support early detection. This work mainly focused a reasonable assessment of various effective machine learning (ML) Algorithms: Logistic Regression (LR), Support Vector Machine (SVM), Decision Tree (DT), Random Forest (RF), XG-Boost, Naive Bayes (NB), and K-Nearest Neighbours (KNN) applied to the publicly available UCI heart disease dataset. To address the critical challenge of explainability in clinical decision support systems, Our proposed dual explainability framework combining Local Interpretable Model-Agnostic Explanations (LIME) and Permutation Feature Importance (PFI) was implemented and evaluated using the publicly available UCI Cleveland Heart Disease dataset (n = 303). The framework achieved robust predictive accuracy and consistent interpretability across multiple machine learning models. While the results demonstrate strong internal validation, they are based solely on this dataset, and future work will extend the framework to larger and multi-institutional datasets to ensure broader clinical generalizability. Finally, performance has been evaluated using accuracy, precision, recall, and F1-score. Among all classifiers, the results show that Random Forest and Decision Tree achieved the highest predictive accuracy of 99%. The combined use of LIME and PFI revealed that features such as ST depression (oldpeak), chest pain type, and maximum heart rate (thalach) consistently influenced predictions. This dual-layer interpretability framework enhances the transparency of ML predictions and supports trustworthy AI-driven decision-making in healthcare. Combines LIME and PFI for dual-level transparency in Healthcare Machine Learning. Presents a rigorous 5$$\times $$5-fold cross-validation, model calibration, and statistical significance testing for reliability. Confirms clinical consistency of top features (ST depression, chest pain, thalach) with cardiology evidence.
Keywords:
Heart Disease
Machine Learning
Explainable AI
LIME
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