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Dual-wavelength tunable molecular logic devices: construction of L₁/L₂ composite systems supported by bovine serum albumin
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DOI：10.1016/j.cplett.2026.142853.png)
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Abstract
En 中文
• Novel Design Strategy: A ternary complex (L1/L2@BSA) was constructed by co-loading two functional fluorescent probes (L1 and L2) onto a bovine serum albumin (BSA) scaffold. This strategy overcomes the inherent limitation of fixed excitation/emission wavelengths in conventional BSA-fluorophore systems, enabling customizable dual-wavelength outputs. • Mechanistic Insights: Mechanistic Insights: Spectroscopic, docking, MD simulation, and thermodynamic analyses reveal that L1 selectively occupies Sudlow site II via hydrogen bonding, while L2 binds primarily to site I through hydrogen bonding. This spatially separated arrangement facilitates efficient energy transfer among BSA, L1, and L2. • Stimuli-Responsive Dual Outputs: The L1/L2@BSA system exhibits precisely tunable fluorescence emissions at 460 nm and 515 nm in response to external chemical stimuli, including pH (H+/OH−) and metal ions (Fe3+, Co2+), with excellent reversibility upon addition of EDTA. • Advanced Molecular Logic Circuits: Utilizing the stimulus-responsive fluorescence, a functionally complete half-subtractor and multi-input (IN1: Co2+, IN2: Fe3+, IN3: EDTA) logic circuits were successfully constructed, demonstrating the system's potential for programmable molecular computing and information processing.
Keywords:
Ternary complex
Dual-wavelength fluorescence
Molecular logic circuits
Stimuli-responsive system
Bovine serum albumin
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