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Dynamic ACE2-Functionalized Magnetic Micromotors for Electrochemical Protein S Detection from SARS-CoV-2: Toward Diagnosis after Virus Mutation
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DOI：10.1021/acssensors.6c00299.png)
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Abstract
En 中文
Inspired by the diagnostic potential of micromotor technology, this study presents a novel magnetic micromotor-based electrochemical biosensing approach for the sensitive detection of spike (S) protein in microliter-scale sample volumes. Tubular MoS2/Ni magnetic micromotors are externally modified with gold nanoparticles (AuNPs) to enable the covalent immobilization of angiotensin-converting enzyme 2 (ACE2) as the capture probe, leveraging its intrinsic recognition capability and resilience to viral mutations for future-proof detection. The inner Ni layer provides biocompatible magnetic propulsion while simplifying washing and handling steps.
Keywords:
Biopolymers
Electrochemical detection
Immunology
Peptides and proteins
SARS-CoV-2
motion
2D nanomaterials
viral diagnostics
enzyme
amperometry
Journal
IF:
9.1
Papers:
975
Citations:
2.6W
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Cited Papers