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Dynamic Coding for Cognitive Control in Prefrontal Cortex
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DOI：10.1016/j.neuron.2013.01.039.png)
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摘要
En 中文
Cognitive flexibility is fundamental to adaptive intelligent behavior. Prefrontal cortex has long been associated with flexible cognitive function, but the neurophysiological principles that enable prefrontal cells to adapt their response properties according to context-dependent rules remain poorly understood. Here, we use time-resolved population-level neural pattern analyses to explore how context is encoded and maintained in primate prefrontal cortex and used in flexible decision making. We show that an instruction cue triggers a rapid series of state transitions before settling into a stable low-activity state. The postcue state is differentially tuned according to the current task-relevant rule. During decision making, the response to a choice stimulus is characterized by an initial stimulus-specific population response but evolves to different final decision-related states depending on the current rule. These results demonstrate how neural tuning profiles in prefrontal cortex adapt to accommodate changes in behavioral context. Highly flexible tuning could be mediated via short-term synaptic plasticity.
Keyword:
SHORT-TERM-MEMORY
WORKING-MEMORY
NEURAL MECHANISMS
NEURONAL-ACTIVITY
INFORMATION
MONKEY
SYNCHRONIZATION
ATTENTION
TARGETS
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期刊
IF:
15
论文数:
1.4W
被引数:
9.9W
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分享收藏分享收藏Synaptic reverberation underlying mnemonic persistent activity助眠持续活动的突触混响.png)
TRENDS IN NEUROSCIENCES
TRENDS IN NEUROSCIENCESIF15.1
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