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Early clearance of Mycobacterium tuberculosis among Indonesian household contacts is not associated with circulating beta-glucan present at the time of exposure

delete2026-05-13
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PRE
AI
T
Todia Pediatama Setiabudiawan *
L
Lika Apriani
M
Marlou Tehupeiory-Kooreman
J
Jochem B. Buil
A
Ayesha J Verrall
A
Andrei Sarlea
M
Mihai G. Netea
B
Bachti Alisjahbana
P
Philip C. Hill
R
Reinout van Crevel
DOI:10.1016/j.tube.2026.102782delete
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Abstract

Abstract

En 中文
• Protection against Mtb infection is associated with increased heterologous cytokine responses among those with a BCG scar, reminiscent of trained immunity • Circulating β-D-glucan which can induce trained immunity is not associated with protection against Mtb infection • Serum from early Mtb clearers does not induce trained immunity ex vivo • Cell-intrinsic epigenetic mechanisms may account for protection against Mtb infection
Keywords:
Trained immunity
Mycobacterium tuberculosis
BCG scar
Cytokine responses
Epigenetic mechanisms

Journal

Tuberculosis cover
Tuberculosis
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2.9
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147
Citations:
3.6K

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universitas padjadjaran
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