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Early clearance of Mycobacterium tuberculosis among Indonesian household contacts is not associated with circulating beta-glucan present at the time of exposure
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DOI:10.1016/j.tube.2026.102782.png)
Abstract
En 中文
• Protection against Mtb infection is associated with increased heterologous cytokine responses among those with a BCG scar, reminiscent of trained immunity • Circulating β-D-glucan which can induce trained immunity is not associated with protection against Mtb infection • Serum from early Mtb clearers does not induce trained immunity ex vivo • Cell-intrinsic epigenetic mechanisms may account for protection against Mtb infection
Keywords:
Trained immunity
Mycobacterium tuberculosis
BCG scar
Cytokine responses
Epigenetic mechanisms
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