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Early onset pancreatic Cancer: epidemiology, molecular features, and clinical outcomes
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DOI：10.1016/j.ctrv.2026.103170.png)
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Abstract
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• Global EOPC cases rose 72.6% from 1990 to 2021 with accelerating birth-cohort trends • Germline pathogenic variants found in 17.3% of EOPC versus 6.4% in older patients • EOPC patients were nearly 3 times more likely to receive cancer-directed treatment • EOPC showed a modest survival benefit over late-onset disease (pooled HR 0.89) • AI-based early detection models achieved AUC up to 0.98 for pancreatic cancer
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