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Early pregnancy GDF15 trajectories and their association with normal gestation, pregnancy loss, and hyperemesis gravidarum

delete2026-08-06
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OA
AI
J
Jens S. Svenningsen *
A
Anne Ostenfeld
J
Jesper Friis Petersen
M
Mikkel Skjoldan Svenningsen
T
Thore Hillig
M
Matthew P. Gillum
T
Trisha J. Grevengoed
E
Ellen Løkkegaard
DOI：10.1016/j.ebiom.2026.106428delete
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Abstract

Abstract

En 中文
Growth differentiation factor 15 (GDF15) rises dramatically in early pregnancy and has been linked to nausea, vomiting, and hyperemesis gravidarum (HG). Significant challenges remain as GDF15 levels overlap between normal and complicated pregnancies, limiting its current clinical utility as a biomarker. Furthermore, early pregnancy GDF15 trajectories remain poorly characterised because most studies lack longitudinal sampling and rely on single or infrequent measurements.
Keywords:
GDF15
Early pregnancy
Hyperemesis gravidarum
PUQE-24
Nausea and vomiting of pregnancy
Pregnancy biomarkers
Longitudinal cohort study
Early pregnancy loss

Journal

EBioMedicine cover
EBioMedicine
IF:
10.8
Papers:
6.4K
Citations:
3.2W

Organization

U
university of copenhagen
Scholars:
6.3K
Papers: 2.5K
Citations: 0
C
copenhagen university hospital
Scholars:
1.6K
Papers: 630
Citations: 0
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