.png){kind=icon}
返回
ECM-inspired micro/nanofibers for modulating cell function and tissue generation
.png){kind=icon}
OA
AI
DOI：10.1126/sciadv.abc2036.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Current homogeneous bioscaffolds could hardly recapture the regenerative microenvironment of extracellular matrix. Inspired by the peculiar nature of dura matter, we developed an extracellular matrix-mimicking scaffold with biomimetic heterogeneous features so as to fit the multiple needs in dura mater repairing. The inner surface endowed with anisotropic topology and optimized chemical cues could orchestrate the elongation and bipolarization of fibroblasts and preserve the quiescent phenotype of fibroblasts indicated by down-regulated a-smooth muscle actin expression. The outer surface could suppress the fibrotic activity of myofibroblasts via increased microfiber density. Furthermore, integrin beta 1 and Yes-associated protein molecule signaling activities triggered by topological and chemical cues were verified, providing evidence for a potential mechanism. The capability of the scaffold in simultaneously promoting dura regeneration and inhibiting epidural fibrosis was further verified in a rabbit laminectomy model. Hence, the so-produced heterogeneous fibrous scaffold could reproduce the microstructure and function of natural dura.
Keyword:
EPIDURAL FIBROSIS
INTEGRIN BETA-1
HIPPO PATHWAY
COLLAGEN
SCAFFOLD
DIFFERENTIATION
MYOFIBROBLASTS
MECHANOBIOLOGY
BIOMATERIALS
ENHANCEMENT
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
12.5
论文数:
2.1W
被引数:
18.1W
机构
引用论文
Harnessing nanotopography and integrin-matrix interactions to influence stem cell fate利用纳米形貌和整合素-基质相互作用影响干细胞命运.png)
NATURE MATERIALS
NATURE MATERIALSIF38.5
PREAI
分享收藏Enhancement of in vitro capillary tube formation by substrate nanotopographyADVANCED MATERIALSOAAI
ADVANCED MATERIALSIF26.8
OAAI分享收藏The involvement of integrin β1 signaling in the migration and myofibroblastic differentiation of skin fibroblasts on anisotropic collagen-containing nanofibers整合素 β1信号参与各向异性胶原纳米纤维上皮肤成纤维细胞的迁移和肌成纤维细胞分化BIOMATERIALSOAAI
BIOMATERIALSIF12.9
OAAI分享收藏E-Spun Composite Fibers of Collagen and Drag line Silk Protein: Fiber Mechanics, Biocompatibility, and Application in Stem Cell DifferentiationBIOMACROMOLECULESOAAI
BIOMACROMOLECULESIF5.4
OAAI分享收藏分享收藏
查看更多内容