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Edible unclonable functions
DOI:10.1038/s41467-019-14066-5.png)
摘要
En 中文
Counterfeit medicines are a fundamental security problem. Counterfeiting medication poses a tremendous threat to patient safety, public health, and the economy in developed and less developed countries. Current solutions are often vulnerable due to the limited security levels. We propose that the highest protection against counterfeit medicines would be a combination of a physically unclonable function (PUF) with on-dose authentication. A PUF can provide a digital fingerprint with multiple pairs of input challenges and output responses. On-dose authentication can verify every individual pill without removing the identification tag. Here, we report on-dose PUFs that can be directly attached onto the surface of medicines, be swallowed, and digested. Fluorescent proteins and silk proteins serve as edible photonic biomaterials and the photoluminescent properties provide parametric support of challenge-response pairs. Such edible cryptographic primitives can play an important role in pharmaceutical anti-counterfeiting and other security applications requiring immediate destruction or vanishing features.
Keyword:
FLUORESCENT SILK
NANOPARTICLES
FIBERS
HEALTH
AUTHENTICATION
FABRICATION
FIBROIN
SAFETY
DRUGS
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期刊
IF:
15.7
论文数:
9.3W
被引数:
91.2W
机构
引用论文
Unbreakable Codes in Electrospun Fibers: Digitally Encoded Polymers to Stop Medicine Counterfeiting
ADVANCED MATERIALS
IF26.8
Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity肥胖中脂肪支链氨基酸分解代谢酶表达和跨脂肪氨基酸通量的调节
Versatile and Validated Optical Authentication System Based on Physical Unclonable Functions基于物理不可克隆功能的通用且经过验证的光学认证系统

