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Effective study design for comparative functional genomics
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DOI：10.1038/s41576-020-0242-z.png)
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Comparative studies struggle to balance technical properties with the need to obtain samples from multiple species. The authors argue for extensive record keeping and reporting of metadata to minimize the effect of confounders and increase the robustness of inferences from these studies. Comparative studies struggle with the challenge of balancing technical properties with the requirement of obtaining samples from multiple species. Guidelines are needed to minimize the effect of confounders and increase the robustness of the inference. We argue for the paramount importance of extensive record keeping and reporting.
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