.png){kind=icon}
返回
Effector-triggered versus pattern-triggered immunity: how animals sense pathogens
.png){kind=icon}
OA
AI
DOI：10.1038/nri3398.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
A fundamental question regarding any immune system is how it can discriminate between pathogens and non-pathogens. Here, we discuss how this discrimination can be mediated by a surveillance system distinct from pattern-recognition receptors that recognize conserved microbial patterns. It can be based instead on the ability of the host to sense perturbations in host cells induced by bacterial toxins or 'effectors' that are encoded by pathogenic microorganisms. Such 'effector-triggered immunity' was previously demonstrated mainly in plants, but recent data confirm that animals can also use this strategy.
Keyword:
PORE-FORMING TOXINS
DAMAGE-RESPONSE FRAMEWORK
BACTERIAL EFFECTORS
INNATE IMMUNITY
TRANSLATIONAL INHIBITION
MICROBIAL PATHOGENESIS
LEGIONELLA-PNEUMOPHILA
ACTIVATION
RECOGNITION
DANGER
期刊
IF:
60.9
论文数:
4.2K
被引数:
6.5W
机构
引用论文
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors模式识别受体在先天免疫中的作用: Toll样受体的更新.png)
NATURE IMMUNOLOGY
OAAI
NATURE IMMUNOLOGYIF27.6
OAAI分享收藏The Pore-Forming Toxin β hemolysin/cytolysin Triggers p38 MAPK-Dependent IL-10 Production in Macrophages and Inhibits Innate ImmunityPLOS PATHOGENSOAAI
PLOS PATHOGENSIF4.9
OAAI分享收藏A Retrospective Study of Peroral Endoscopic Full-Thickness Myotomy in Patients with Severe Achalasia
PREAI
分享收藏分享收藏
查看更多内容