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Effects of aging on T cell function
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DOI：10.1016/j.coi.2009.05.009.png)
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摘要
En 中文
Immunosenescence influences many components of the immune system. Most importantly, profound changes in T cell function are evident in older individuals. The impact of aging on specific T cell subsets has been difficult to examine, but recent advances in murine model systems and new insights into T cell function have allowed for the more precise examination of how T cell responses change with aging. Importantly, recent studies have shown that age-related enhancement of both Th17 generation and regulatory T cell function may contribute to significant changes in immune function. In this review, we summarize the current views on how aging influences the factors that impact T cell function and how this can affect the immune response to infections, vaccinations, and tumors.
Keyword:
AGE-RELATED DEFECTS
CLONAL EXPANSIONS
GERMINAL-CENTERS
IN-VIVO
OLD-AGE
CD4
MICE
CYTOKINES
RESPONSES
IMMUNITY
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5.8
论文数:
3.4K
被引数:
9.5K
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引用论文
Interleukin 2, but not other common γ chain-binding cytokines, can reverse the defect in generation of CD4 effector T cells from naive T cells of aged mice白细胞介素2，而不是其他常见的 γ 链结合细胞因子，可以逆转老年小鼠幼稚T细胞产生CD4效应T细胞的缺陷OAAI
OAAI分享收藏High accumulation of T regulatory cells prevents the activation of immune responses in aged animals
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OAAI分享收藏Nuclear factor-κB-dependent reversal of aging-induced alterations in T cell cytokines.png)
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FASEB JOURNALIF4.2
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