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Effects of Sanghuangporus vaninii and Calvatia gigantea polysaccharide hydrogels on DNFB-induced atopic dermatitis in mice
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DOI：10.2306/scienceasia1513-1874.2026.041.png)
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Abstract
En 中文
Atopic dermatitis (AD), a chronic inflammatory skin disorder that affects more than 20% of children and 10% of adults globally, requires novel therapeutic strategies. Sanghuangporus vaninii (S. vaninii) and Calvatia gigantea (C. gigantea) are medicinal fungi that have anti-inflammatory and immunomodulatory properties. In this study, we extracted and purified the total polysaccharides of S. vaninii (SVP) and C. gigantea (CGP) and prepared two types of polysaccharide-based hydrogels for AD treatment. The hydrogels exhibited porous microstructures and high hydration capacities. In a standardized 2,4-dinitrofluorobenzene (DNFB)-induced AD mouse model, both SVP and CGP-hydrogels demonstrated significant therapeutic efficacy, with SVP showing a more pronounced effect. The SVP and CGP-hydrogels reduced dermatitis scores and ear thickness after a 14-day treatment period. Histopathological analysis revealed that SVP and CGP-hydrogels suppressed epidermal hyperplasia and mast cell infiltration. RT-qPCR and Elisa analysis showed that SVP and CGP-hydrogels significantly downregulated the express levels of pro-inflammatory cytokines (TNF-alpha, IL-1 beta and IL-6) and upregulated the anti-inflammatory cytokines IL-10. Notably, SVP-hydrogel could affect the expression levels of Th1 and Th2 cell-specific cytokines in AD mice, suggesting that SVP may be used to treat AD by restoring immune balance. These findings indicate that SVP and CGP-hydrogels are promising adjuvant therapies for AD.
Keywords:
atopic dermatitis
Sanghuangporus vaninii polysaccharide
Calvatia gigantea polysaccharide
hydrogel
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