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Efficacy and safety of antibiotics in the treatment of multidrug-resistant Acinetobacter baumannii infections: a systematic review and Bayesian network meta-analysis
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DOI：10.1016/j.jgar.2026.04.016.png)
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Abstract
En 中文
• Cefiderocol-based therapies ranked highest for mortality reduction. • Sulbactam–durlobactam ranked first for clinical and microbiological cure. • Most evidence was derived from cohort studies with very low certainty. • Findings cannot substitute for randomized comparisons. • baumannii-specific trials are needed to validate these findings.
Keywords:
Antimicrobial resistance
Multidrug-resistant
Acinetobacter baumannii
Network meta-analysis
A. baumannii
Acinetobacter baumannii
APACHE II
Acute Physiological Assessment and Chronic Health Evaluation II
BGR
Brooks–Gelman–Rubin
CLSI
Clinical and Laboratory Standards Institute
CR
Carbapenem-resistant
CrI
Credible interval
DIC
Deviance information criterion
ESCMID
European Society of Clinical Microbiology and Infectious Diseases
EUCAST
European Committee on Antimicrobial Susceptibility Testing
FDA
U.S. Food and Drug Administration
GNB
Gram-negative bacteria
GRADE
Grading of Recommendations Assessment, Development and Evaluation
HAP
Hospital-acquired pneumonia
IDSA
Infectious Diseases Society of America
KDIGO
Kidney Disease: Improving Global Outcomes
MCMC
Markov Chain Monte Carlo
MDR
Multidrug-resistant
MIC
Minimum inhibitory concentration
MIU
Million international units
NMA
Network meta-analysis
OR
Odds ratio
PBP
Penicillin-binding protein
PICOS
Population, intervention, comparison, outcomes and study design
PRISMA
Preferred Reporting Items for Systematic Reviews and Meta-Analyses
RCT
Randomized controlled trial
RIFLE
Risk, injury, failure, loss, end-stage kidney disease
RoB
Risk of bias
ROBIN-I
Risk of bias in non-randomized studies of interventions
SUCRA
Surface under the cumulative ranking curve
TDM
Therapeutic drug monitoring
VAP
Ventilator-associated pneumonia
wj
Weighting parameter
XDR
Extensively drug-resistant
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