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Efficacy and Safety of Calcium Hydroxylapatite for Nasal Augmentation: A 12-Month Prospective Study in a Chinese Population
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DOI：10.1111/jocd.70862.png)
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Abstract
En 中文
Background Calcium hydroxylapatite (CaHA) is a biostimulatory material that induces collagen neogenesis, but its long-term volumetric dynamics following nasal injection remain insufficiently characterized. This study aimed to evaluate the efficacy and safety of CaHA gel for nasal augmentation in a Chinese population. Methods In this prospective study, 24 female patients received CaHA injections for nasal augmentation. Efficacy was assessed with three-dimensional (3D) facial scanning at 0 (immediately after injection), 1, 3, 6, 9, and 12 months. Patient satisfaction was evaluated using the Global Aesthetic Improvement Scale (GAIS). Safety was assessed by the Numerical Rating Scale (NRS) for injection-related pain and recording of injection site adverse reactions. Results All 24 patients completed the 12-month follow-up. 3D volumetric analysis revealed a transient reduction from Month 0 to Month 1 (p < 0.05), followed by a modest numerical increase from Month 1 to Month 6 that did not reach statistical significance (p > 0.05). At Month 12, the volume was 0.94 +/- 0.45 mL, representing a significant decline compared with Months 6 and 9 (p < 0.05). The GAIS responder rate (subjects rating Much improved or Very much improved) was 79% at Month 3 and 58% at Month 9. Injection-related pain was mild (mean NRS at 0 min: 1.29) and resolved within 60 min. Adverse events were transient, primarily swelling (60.5%) and tenderness (21.1%), resolving spontaneously within 1 week. No serious complications occurred. Conclusions CaHA injection is an effective and safe treatment for nasal augmentation, providing durable volumetric improvement and high patient satisfaction over 12 months.
Keywords:
biostimulatory material
calcium hydroxylapatite
mid-face rejuvenation
nasal augmentation
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