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Efficacy of ARNIs on Hard Renal Outcomes in Heart Failure with and without Chronic Kidney Disease: When Endpoint Definition Matters—An Updated Meta-Analysis

delete2026-06-05
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OA
AI
G
Giuseppe Cianciolo
D
Daniele Vetrano
A
Alessandro Tomassetti
E
Edoardo Tringali
M
Massimo Iacoviello
S
Stefania Marazia
A
Alessandro Fucili
G
Gaetano La Manna
A
Antonio De Pascalis *
DOI：10.1093/eschf/xvag148delete
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Abstract

Abstract

En 中文
The renal effects of sacubitril/valsartan (Sac/Val) in heart failure (HF) remain incompletely defined, partly because kidney outcomes in pivotal HF trials have been variably prespecified and heterogeneously defined. We performed an updated systematic review and meta-analysis to assess whether the apparent renal signal of Sac/Val varies according to endpoint definition.

Journal

ESC Heart Failure cover
ESC Heart Failure
IF:
3.7
Papers:
3.3K
Citations:
9.1K

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I
IRCCS Azienda Ospedaliero-Universitaria di Bologna
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1.1K
Papers: 378
Citations: 0
U
University of Foggia
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A
asl lecce
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A
azienda ospedaliero-universitaria di ferrara
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20
Papers: 7
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A
alma mater studiorum - university of bologna
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22
Papers: 9
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A
asl to4
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6
Papers: 5
Citations: 2
V
vito fazzi hospital
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71
Papers: 55
Citations: 0
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