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Efficacy of Melatonin as an Adjunct to Non-Surgical Periodontal Therapy: A Systematic Review and Meta-Analysis
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DOI：10.1016/j.jebdp.2026.102270.png)
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Abstract
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• Adjunctive melatonin with NSPT improves CAL and PPD at 2 months, with smaller effects at 3-6 months. • Prediction intervals for CAL and PPD crossed the null, indicating uncertainty in reproducibility. • No statistically significant effect modification was observed by administration route. • Adjunctive melatonin improves HbA1c in patients with type 2 diabetes. • Certainty of evidence was moderate for short-term CAL, PPD, and HbA1c outcomes.
Keywords:
Melatonin
Periodontal diseases
Scaling root planing
Adjunctive therapy
Clinical attachment
Probing depth
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