.png){kind=icon}
.png){kind=icon}
Return
Electrophysiological Biomimicry: Engineering Bone Regeneration With Ceramics and Glasses
.png){kind=icon}
PRE
AI
M
DOI：10.1111/jace.70949.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Bone regeneration is regulated by mechanical forces, biochemical gradients, and endogenous electrical cues, which collectively guide cellular behavior during repair and remodeling. The bone's electrophysiological environment arises from overlapping effects, including piezoelectricity, pyroelectricity, ferroelectricity, dielectric properties, and streaming potentials, all generated by routine mechanical activity. This environment plays a central role in bone metabolism and regeneration. Understanding bone as a natural electroactive composite informs the design of advanced biomaterials. Replicating these electrical cues is a promising approach for developing biomaterials that actively promote bone regeneration. This review examines the biological origins of electrical phenomena in bone, including streaming potentials, piezoelectricity, and ion-mediated signaling, and their roles in osteogenesis, angiogenesis, and immune modulation. We evaluate how electroactive ceramics and glasses generate electrical stimulation through piezoelectric, ferroelectric, and magnetoelectric mechanisms, influencing cellular activity and tissue repair. Recent developments in composite systems, multifunctional scaffolds, and smart platforms are highlighted. Key challenges discussed include long-term electrical stability, scalable manufacturing, sterilization, safety, and regulatory compliance. By integrating knowledge from bone electrophysiology, materials science, and biomedical translation, this review outlines a pathway for engineering smart ceramic- and glass-based biomaterials that replicate endogenous electrophysiology to support bone regeneration.
Keywords:
bioelectric signaling
bone regeneration
electroactive biomaterials
electrophysiological environment
ferroelectric and piezoelectric ceramics
ionically conductive composites
mechanotransduction
Journal
IF:
3.8
Papers:
1.7W
Citations:
5.4W
Organization
Cited Papers