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Elevated FN14 expression promotes proliferation, chemoresistance, and impairment of differentiation in rhabdomyosarcoma
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DOI：10.1016/j.canlet.2026.218768.png)
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Abstract
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• FN14 expression is significantly elevated in human rhabdomyosarcoma (RMS) tissues and RMS cell lines. • Silencing of FN14 suppresses proliferation and survival while promoting differentiation of RMS cells and is associated with reduced ERK1/2 activation. • FN14 depletion reduces mitochondrial oxidative phosphorylation in RMS cells. • FN14 expression is increased in vincristine-resistant RD cells, and its knockdown enhances chemosensitivity.
Keywords:
FN14
TWEAK
Rhabdomyosarcoma
Mitochondrial respiration
ERK1/2 signaling
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