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Elevated Serum d-ROMs and Lesional 4-HNE Expression Indicate Oxidative Stress in Pemphigus
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DOI：10.1016/j.jdermsci.2026.03.006.png)
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Abstract
En 中文
• Serum oxidative stress was elevated in patients with pemphigus and decreased after one month of therapy. • Circulating oxidative stress levels correlated with clinical disease severity. • 4-HNE, a lipid peroxidation marker, was strongly expressed in epidermal keratinocytes of lesional skin, especially in acantholytic areas. • Oxidative stress acts as a potential driver of keratinocyte damage and the pathogenesis of pemphigus.
Keywords:
BAP
biological antioxidant potential
d-ROMs
diacron-reactive oxygen metabolites
4-HNE
4-hydroxy-2-nonenal
PDAI
Pemphigus Disease Area Index
ROS
reactive oxygen species
U.CARR
Carratelli units
oxidative stress
pemphigus
diacron-reactive oxygen metabolites
biological antioxidant potential
4-hydroxy-2-nonenal
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