Emerging approaches for T cell-stimulating platform development

Emily Ariail

doi:10.1016/j.cels.2024.11.007

2024-12-01

PRE

DOI：10.1016/j.cels.2024.11.007

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T细胞是适应性免疫反应的关键介导者，在破坏外来病原体威胁以及病理转化的宿主细胞方面发挥着直接和支持性作用。T细胞被激活的自然过程需要抗原呈递细胞和T细胞之间协调的分子相互作用。生物材料设计方面的有前景的进展已催化了人工平台的发展，这些平台模拟T细胞刺激的自然过程，旨在通过在过继细胞转移前体外激活T细胞来增强细胞疗法的效果，以及作为即用型治疗直接在体内激活T细胞。本文重点介绍了用于癌症治疗应用的T细胞刺激平台设计中的创新策略。我们特别强调了在基于微珠的人工抗原呈递细胞工程、基于水凝胶的支架、基于DNA的系统、替代聚合物策略和可溶性激活方法方面的进展。总体而言，这些进展正在扩展靶向免疫激活的工具库。

Keyword:

ANTIGEN-PRESENTING CELLS

ANTITUMOR IMMUNITY

IN-VIVO

ACTIVATION

EXPANSION

CD4(+)

ENHANCEMENT

EFFECTOR

期刊

Cell Systems

IF:

7.7

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1.4K

被引数:

1.0W

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