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Emerging perspectives on metabolic reprogramming in the microenvironment of ovarian cancer metastasis
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DOI：10.1016/j.bbcan.2026.189554.png)
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Abstract
En 中文
• Ovarian cancer (OC) metastasis is driven by metabolic reprogramming in response to physical factors like hypoxia, shear stress, and extracellular acidification within the peritoneal microenvironment. • Cancer-associated fibroblasts (CAFs) and adipocytes engage in metabolic crosstalk with OC cells, promoting metastatic progression and therapeutic resistance. • Immunometabolism plays a critical role in OC metastasis, with tumor-associated macrophages (TAMs) and T cells undergoing metabolic reprogramming to influence tumor progression. • Emerging factors such as the microbiome and cellular senescence reshape the metabolic landscape of OC, offering new insights into metastatic mechanisms. • Clinical trials targeting metabolic pathways highlight promising therapeutic strategies for combating ovarian cancer metastasis and improving patient outcomes.
Keywords:
Metabolic reprogramming
Ovarian cancer metastasis
Peritoneal microenvironment
Cancer-associated fibroblasts
Immunometabolism
Journal
B
IF:
0
Papers:
105
Citations:
0
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Cited Papers