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Emerging roles of m6A in female reproductive disorders: from molecular mechanisms to therapeutic targets
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DOI：10.1007/s10815-026-03953-8.png)
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Abstract
En 中文
N6-methyladenosine (m6A), the dominant internal RNA modification in eukaryotic mRNA, plays an important regulatory role in female reproductive physiology and associated pathologies. This review systematically outlines the precise regulatory mechanisms exerted by m6A writers, erasers, and readers in core processes including germ cell development, early embryogenesis, and hormone signaling. We further elaborate on how aberrant m6A modifications contribute to the pathogenesis of various female reproductive disorders, such as gynecological cancer, polycystic ovary syndrome, and preeclampsia. In addition, we conducted a rigorous assessment of the therapeutic and diagnostic potential targeting the m6A mechanism. By synthesizing mechanistic insights from both neoplastic and non-neoplastic diseases, this review provides a comprehensive framework for understanding the epitranscriptomic governance of female reproductive health and proposes new directions for future research and clinical translation.
Keywords:
N6-methyladenosine (m6a)
Epigenetic modification
M6A detection technology
Female reproductive diseases
Female reproductive development
Treatment strategy
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2.7
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5.9K
Citations:
9.4K
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