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Enantioselective Self-Replicators
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DOI：10.1021/jacs.3c05472.png)
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摘要
En 中文
Self-replicating molecules provide a simple approachfor investigatingfundamental processes in scenarios of the emergence of life. Althoughhomochirality is an important aspect of life and of how it emerged,the effects of chirality on self-replicators have received only littleattention so far. Here, we report several self-assembled self-replicatorswith enantioselectivity that emerge spontaneously and grow only fromenantiopure material. These require a relatively small number of chiralunits in the replicators (down to eight) and in the precursors (downto a single chiral unit), compared to the only other enantioselectivereplicator reported previously. One replicator was found to incorporatematerial of its own handedness with high fidelity when provided witha racemic mixture of precursors, thus sorting (L)- and (D)-precursorsinto (L)- and (D)-replicators. Systematic studies reveal that thepresence or absence of enantioselectivity depends on structural features(ring size of the replicator) that appear to impose constraints onits supramolecular organization. This work reveals new aspects ofthe little researched interplay between chirality and self-replicationand represents another step toward the de novo synthesis of life.
Keyword:
ASYMMETRIC AUTOCATALYSIS
SYSTEMS CHEMISTRY
EMERGENCE
HOMOCHIRALITY
AMPLIFICATION
DRIVEN
ORIGIN
LIFE
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期刊
IF:
15.6
论文数:
20.0W
被引数:
60.2W
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