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Encapsulation of protein/DNA complexes into unilamellar liposomes via annexin-mediated membrane recruitment and sonication
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DOI：10.1016/j.crmeth.2025.101073.png)
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Abstract
En 中文
• Annexin A4 enables calcium-dependent membrane recruitment of DNA-protein complexes • Sonication of coated GUVs yields unilamellar vesicles with encapsulated TFAMoplex • Approximately 40% of TFAMoplexes are protected within vesicles from nucleases • The method achieves DNA/protein encapsulation under aqueous, physiological conditions
Keywords:
DNA encapsulation
protein encapsulation
liposomes
biotechnology
protein engineering
DNA delivery
synthetic biology
membrane recruitment
large unilamellar vesicle
giant unilamellar vesicle
CP: biotechnology