.png){kind=icon}
返回
Endurance training attenuates the decrease in skeletal muscle malonyl-CoA with exercise
.png){kind=icon}
OA
AI
DOI：10.1152/jappl.1997.83.6.1917.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
Muscle malonyl-CoA has been postulated to regulate fatty acid metabolism by inhibiting carnitine palmitoyltransferase 1. In nontrained rats, malonyl-CoA decreases in working muscle during exercise. Endurance training is known to increase a muscle's reliance on fatty acids as a substrate. This study was designed to investigate whether the decline in malonyl-CoA with exercise would be greater in trained than in nontrained muscle, thereby allowing increased fatty acid oxidation. After 6-10 wk of endurance training (2 h/day) or treadmill habituation (5-10 min/day), rats were killed at rest or after running up a 15% grade at 21 m/min for 5, 20, or 60 min. Training attenuated the exercise-induced drop in malonyl-CoA and prevented the exercise-induced increase in the constant for citrate activation of acetyl-CoA carboxylase in the red quadriceps muscle of rats run for 20 and 60 min. Hence, contrary to expectations, the decrease in malonyl-CoA was less in trained than in nontrained muscle during a single bout of prolonged submaximal exercise.
Keyword:
muscle acetyl-CoA carboxylase
carnitine palmitoyltransferase
fatty acid oxidation
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
3.3
论文数:
1.5W
被引数:
4.0W
机构
暂无机构信息
引用论文
Contraction-induced changes in acetyl-CoA carboxylase and 5'-AMP-activated kinase in skeletal muscleOAAI
.png){kind=icon}
OAAI分享收藏分享收藏Moving Toward Space Internetworking via DTN: Its Operational Challenges, Benefits and Management
PREAI
分享收藏
查看更多内容