Engineered Peptide Repairs Defective Adhesive-Dentin Interface

doi:10.1002/mame.201600487

2017-02-15

DOI：10.1002/mame.201600487

原文链接

查看原文

摘要

En 中文

Failure of dental composite restorations is primarily due to recurrent decay at the tooth-composite interface. At this interface, the adhesive and its bond with dentin is the barrier between the restored tooth and the oral environment. In vivo degradation of the bond formed at the adhesive/dentin (a/d) interface follows a cascade of events leading to weakening of the composite restoration. Here, a peptide-based approach is developed to mineralize deficient dentin matrices at the a/d interface. Peptides that have an inherent capacity to self-assemble on dentin and to induce calcium-phosphate remineralization are anchored at the interface. Distribution of adhesive, collagen, and mineral is analyzed using micro-Raman spectroscopy and fluorescence microscopy. The analysis demonstrates remineralization of the deficient dentin matrices achieved throughout the interface with homogeneous distribution of mineral. The peptide-based remineralization demonstrated here can be an enabling technology to design integrated biomaterial-tissue interfaces.

Keyword:

adhesive

dentin interface

composite restorative materials

material-tissue interface

mineralization

peptides

AI总结

对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。

期刊

Macromolecular Materials and Engineering

IF:

4.6

论文数:

4.2K

被引数:

9.5K

机构

暂无机构信息

引用论文

Patient Risk Factors' Influence on Survival of Posterior Composites

JOURNAL OF DENTAL RESEARCH

IF5.9

2013-05-20

176

PREAI

van de Sande, F. H.; Opdam, N. J.; Da Rosa Rodolpho, P. A.; Correa, M. B.; Demarco, F. F.; Cenci, M. S.

Biomimetic Silicification of Demineralized Hierarchical Collagenous Tissues

BIOMACROMOLECULES

IF5.4

2013-04-26

OAAI

Niu, Li-na; Jiao, Kai; Ryou, Heonjune; Diogenes, Anibal; Yiu, Cynthia K. Y.; Mazzoni, Annalisa; Chen, Ji-hua; Arola, Dwayne D.; Hargreaves, Kenneth M.; Pashley, David H.; Tay, Franklin R.

The Effect of Added Alcohols on the Solubility and the Krafft Point of Sodium Dodecyl Sulfate

The Journal of Physical Chemistry

IF0

2002-05-01

PREAI

H. Nakayama; Kozo Shinoda; E. Hutchinson

Micromechanical analysis of dentin/adhesive interface by the finite element method

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

IF3.4

2004-04-09

OAAI

Misra, A; Spencer, P; Marangos, O; Wang, Y; Katz, JL