.png){kind=icon}
返回
Engineered selective biotoxin-binding hydrogels for toxin sequestration
.png){kind=icon}
OA
AI
DOI：10.1002/pol.20230788.png)
.png){kind=icon}
原文求助.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
The development of synthetic selective membranes that separate materials of similar sizes, charges, and/or polarities remains a difficult challenge, and looking towards biology provides inspiration for new designs. In this work, a series of cholera toxin binding peptides (CTBPs) are identified, spanning a range of binding inhibitions, and integrated into chemically cross-linked cholera toxin binding gels (CTBGs) via thiol-Michael polycondensation reactions. All gels demonstrate rheological profiles consistent with elastic solids. The CTBGs are probed via small-angle neutron scattering and exhibit a correlation length, xi, smaller than most proteins (1.3-2.5 nm). Thus, an effective entropic mesh is formed to block non-targeted proteins. However, the CTBGs have a dynamic mesh size, Xi, that is larger than cholera toxin (CT) to allow the transport of target proteins. The CTBGs with the highest binding inhibitions both show high selectivity and permeation of CT, rejecting all other tested proteins. In total, two new highly selective CTBGs are synthesized and validated for use in cholera toxin remediation. Together, this platform demonstrates the wide applicability of selectively-diffusive materials for difficult separations. image
Keyword:
biomacromolecules
cholera
hydrogels
selective membranes
toxin sequestration
期刊
IF:
3.6
论文数:
2.3K
被引数:
6.4K
机构
暂无机构信息
引用论文
Theory of Localization and Activated Hopping of Nanoparticles in Cross-Linked Networks and Entangled Polymer Melts.png)
MACROMOLECULES
MACROMOLECULESIF5.2
PREAI
分享收藏
Factorial screening of antibody purification processes using three chromatography steps without protein A使用三个色谱步骤在没有蛋白A的情况下对抗体纯化过程进行因子筛选
PREAI
分享收藏Artificially Engineered Protein Hydrogels Adapted from the Nucleoporin Nsp1 for Selective Biomolecular TransportADVANCED MATERIALSOAAI
ADVANCED MATERIALSIF26.8
OAAI分享收藏
查看更多内容