Engineered Tissue Models to Decode Host-Microbiota Interactions

Miryam Adelfio

doi:10.1002/advs.202417687

2025-05-14

DOI：10.1002/advs.202417687

原文链接

原文求助

摘要

En 中文

人体内宿主与其相关微生物群之间存在互利共进化关系。细菌在身体的各个组织中建立生态位，局部影响其生理功能和功能，同时通过与其他远端生态位（轴）的系统通信，为整个机体的健康做出贡献。新兴证据表明，当栖息于生态位的微生物群组成向致病状态（失调）转变且与宿主的相互作用失衡时，可能导致疾病的发生。此外，单个生态位内的失衡也可能导致远端器官的失调。当前的研究重点是阐明导致失调的机制，旨在恢复组织稳态。体外模型可通过高保真度再现生态位的细胞架构和生理功能，为解决这一需求提供关键实验平台。本文综述了当前的体外宿主-微生物群研究策略，并提供了一份路线图，以指导该领域进一步开发具有生理相关性的生态位体外模型，从而能够探究微生物群在人类健康和疾病中的作用。最后，鉴于《食品药品监督管理局现代化法案2.0》，本文重点介绍了支持新疗法上市开发和验证的新兴体外策略。

Keyword:

dysbiosis

female reproductive tract

host-microbiome interactions

intestine

oral

skin

tissue models

期刊

Advanced Science

IF:

14.1

论文数:

1.8W

被引数:

11.5W

机构

Univ Massachusetts Lowell

学者数:

141

论文数: 78

被引数: 12

ADA Forsyth Inst

学者数:

论文数: 7

被引数: 4

引用论文

Local and systemic cytokine levels in relation to changes in vaginal flora

JOURNAL OF INFECTIOUS DISEASES

IF4.5

2006-02-15

144

PREAI

Hedges, SR; Barrientes, F; Desmond, RA; Schwebke, JR

Transfusion‐transmitted HBV infection with isolated anti‐HBs‐positive blood

Transfusion

IF0

2023-05-02

PREAI

Masahiro Satake; Naoji Yamagishi; Ami Tanaka; Naoko Goto; Tomohiko Sakamoto; Yusuke Yanagino; Rika A. Furuta; Keiji Matsubayashi

Numerical micromagnetic simulation of Fe–Pt nanoparticles with multiple easy axes

Journal of Magnetism and Magnetic Materials

IF0

2004-05-01

PREAI

Werner Scholz; Josef Fidler; Thomas Schrefl; Dieter Suess; Hermann Forster; Rok Dittrich; Vassilios Tsiantos

Characterization of damage induced by heavy neutron irradiation on multilayered L6iF-single crystal chemical vapor deposition diamond detectors

Journal of Applied Physics

IF0

2009-10-02

OAAI

S. Almaviva; M. Angelone; Marco Marinelli; E. Milani; M. Pillon; G. Prestopino; A. Tucciarone; C. Verona; G. Verona-Rinati

Incidental movement, lifestyle-embedded activity and sleep: new frontiers in physical activity assessmentThis article is part of a supplement entitled Advancing physical activity measurement and guidelines in Canada: a scientific review and evidence-based foundation for the future of Canadian physical activity guidelines co-published by Applied Physiology, Nutrition, and Metabolism and the Canadian Journal of Public Health. It may be cited as Appl. Physiol. Nutr. Metab. 32(Suppl. 2E) or as Can. J. Public Health 98(Suppl. 2).

Applied Physiology, Nutrition, and Metabolism

IF0

2007-11-01

OAAI

Mark S. Tremblay; Dale W. Esliger; Angelo Tremblay; Rachel Colley

Some problems in cationic polymerization of heterocyclic compounds. Review

Polymer Science U.S.S.R.

IF0

1977-01-01

PREAI

N.S. Yenikolopyan; V.V. Ivanov; G.V. Korovina; M.A. Markevich; T.I. Prokof'eva; A.T. Ponomarenko; G.V. Rakova

A new color reaction for the determination of aldopentose in presence of other saccharides

Biochimica et Biophysica Acta

IF0

1957-01-01

PREAI

Zacharias Dische; Ellen Borenfreund

Structure and accountability a study of national nonprofit associations

Nonprofit Management and Leadership

IF0

2006-09-12

PREAI

Dennis R. Young; Neil Bania; Darlyne Bailey

Abstract 16059: Racial and Ethnic Differences in Preserved Ejection Fraction and Reduced Ejection Fraction Incident Heart Failure in a Multiracial Cohort of Post-Menopausal Women

Circulation

IF0

2014-11-25

PREAI

Abdullah Quddus; Liviu Klein; Jacques E Rossouw; Wen-Chih Wu; Simin Liu; Nina S Wampler; Lisa W Martin; Karen Margolis; Karen Johnson; Randi Foraker; Giselle Corbie-Smith; Khadijah Breathett; Matthew Allison; Joanne E Manson; Charles B Eaton

Probabilistic seasonal rainfall forecasts using semiparametric d-vine copula-based quantile regression

Handbook of Probabilistic Models

IF0

2020-01-01

PREAI

Thong Nguyen-Huy; Ravinesh C. Deo; Shahbaz Mushtaq; Shahjahan Khan

查看更多内容