Engineering challenges for brain tumor immunotherapy

Johnathan G. Lyon

doi:10.1016/j.addr.2017.06.006

2017-05-01

Ravi V. Bellamkonda *

DOI：10.1016/j.addr.2017.06.006

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摘要

En 中文

Malignant brain tumors represent one of the most devastating forms of cancer with abject survival rates that have not changed in the past 60 years. This is partly because the brain is a critical organ, and poses unique anatomical, physiological, and immunological barriers. The unique interplay of these barriers also provides an opportunity for creative engineering solutions. Cancer immunotherapy, a means of harnessing the host immune system for anti-tumor efficacy, is becoming a standard approach for treating many cancers. However, its use in brain tumors is not widespread. This review discusses the current approaches, and hurdles to these approaches in treating brain tumors, with a focus on immunotherapies. We identify critical barriers to immunoengineering brain tumor therapies and discuss possible solutions to these challenges. (C) 2017 The Author(s). Published by Elsevier B.V.

Keyword:

Brain cancer

Immunotherapy

Blood-brain barrier

Lymphatics

Tumor-associated microglia

Neuroimmunology

Glioblastoma

Neurooncoimmunology

Immunoengineering

Immunomodulation

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期刊

Advanced Drug Delivery Reviews

IF:

17.6

论文数:

4.5K

被引数:

5.1W

机构

Duke University

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6.3W

论文数: 5.7W

被引数: 6.5W

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