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Enhancing Photodynamic and Chemodynamic Therapy Efficacy through a Novel ROS-Amplifying Therapeutic Platform for Breast Cancer Treatment
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DOI：10.1039/D6NH00034G.png)
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Abstract
En 中文
Suboptimal reactive oxygen species (ROS) production in photodynamic therapy (PDT) and chemodynamic therapy (CDT) due to tumor antioxidants and H2O2 constraints poses a challenge to their therapeutic efficacy. To address this; our study introduces GOx@MPN@Gel; a novel PDT/CDT platform that integrates glucose oxidase (GOx); luteolin; iron ions; a traditional Chinese medicine-inspired metal-phenolic network (MPN); and hydrogel (Gel) carriers to enhance ROS generation. Experimental results demonstrate GOx@MPN@Gel heightened acid sensitivity; robust GOx activity; and significant ROS production. Both in vitro and in vivo tests validate its therapeutic potential. Within the tumor microenvironment; GOx@MPN@Gel effectively elevates H2O2 levels for CDT; producing cytotoxic hydroxyl radicals (·OH); and upon near infrared (NIR) light exposure; its porphyrin component triggers potent PDT effects; generating additional ROS. This synergistic approach significantly enhances antitumor efficacy. The platform's unique design; combining acid-responsive degradation and PDT/CDT synergy; offers a promising personalized treatment strategy for breast cancer.
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