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Enterococci facilitate polymicrobial infections
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DOI：10.1016/j.tim.2023.07.010.png)
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摘要
En 中文
Enterococci are ubiquitous members of the gut microbiota in human beings animals and are among the most important nosocomial organisms. Due to opportunistic pathogenicity, enterococci are referred to as pathobionts play decisive roles in a diverse array of polymicrobial infections. Enterococci can promote the colonization, pathogenesis, and persistence of various pathogens, compromise the efficacy of drugs, and pose a severe threat to public health. Most current treatments tend to focus on the sole pathogenic bacteria, with insufficient attention to the driving role of enterococci. In this review, summarize the characteristics of enterococci in infections, the factors facilitating their outgrowth, as well as the sites and types of enterococci-associated polymicrobial infections. We present an overview of the underlying mechanisms of enterococci-mediated pathogenesis in polymicrobial infections. Furthermore, we discuss alternative strategies and potential intervention approaches to strict such infections, shedding light on the discovery and development of therapies against polymicrobial infections.
Keyword:
VANCOMYCIN-RESISTANT ENTEROCOCCI
STAPHYLOCOCCUS-AUREUS
INTESTINAL MICROBIOTA
FAECALIS
COLONIZATION
FAECIUM
PATHOGENS
VANA
AMINOGLYCOSIDE
MANAGEMENT
期刊
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14.9
论文数:
3.9K
被引数:
1.9W
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