.png){kind=icon}
返回
Enzyme function and its evolution
.png){kind=icon}
OA
AI
DOI：10.1016/j.sbi.2017.10.004.png)
.png){kind=icon}
.png){kind=icon}
分享.png){kind=icon}
收藏
摘要
En 中文
With rapid increases over recent years in the determination of protein sequence and structure, alongside knowledge of thousands of enzyme functions and hundreds of chemical mechanisms, it is now possible to combine breadth and depth in our understanding of enzyme evolution. Phylogenetics continues to move forward, though determining correct evolutionary family trees is not trivial. Protein function prediction has spawned a variety of promising methods that offer the prospect of identifying enzymes across the whole range of chemical functions and over numerous species. This knowledge is essential to understand antibiotic resistance, as well as in protein re-engineering and de novo enzyme design.
Keyword:
PROTEIN FUNCTION
STRUCTURAL CLASSIFICATION
FUNCTION PREDICTION
GENE ONTOLOGY
MECHANISM
ANNOTATIONS
HOMOLOGY
ORIGIN
SCOP
AI总结
对已上传原文的论文进行重点信息的提取，主要内容包括：简要概述、研究摘要、背景介绍、关键亮点、图文解析、展望与总结。
期刊
IF:
7
论文数:
3.8K
被引数:
1.3W
机构
引用论文
APRICOT: an integrated computational pipeline for the sequence-based identification and characterization of RNA-binding proteins.png)
NUCLEIC ACIDS RESEARCHOAAI
NUCLEIC ACIDS RESEARCHIF13.1
OAAI分享收藏
FFPred 3: feature-based function prediction for all Gene Ontology domainsSCIENTIFIC REPORTSOAAI
SCIENTIFIC REPORTSIF3.9
OAAI分享收藏Quantitative Comparison of Catalytic Mechanisms and Overall Reactions in Convergently Evolved Enzymes: Implications for Classification of Enzyme Functionplos biologyOAAI
plos biologyIF3.6
OAAI分享收藏
查看更多内容